Franaux, M., Louis, M., Sturbois, X., & Poortmans, J. R. (2001). Effects of creatine supplementation in males and females. Medicine and Science in Sports and Exercise, 33(5), Supplement abstract 1152.

Males (N = 20) and females (N = 20) were subdivided into creatine supplementation and placebo groups. Supplementation lasted 28 days. For the first five days, Ss received either 21 g/day of creatine or placebo. For the remaining days, creatine supplementation was 3 g/day. Maximal power output of knee extensions was measured. After 15 minutes of recovery, Ss performed a fatigue test, raising the leg once every five seconds with a load corresponding to the mean power output produced in the previous test.

Mean power output increased in both creatine groups. Performance to fatigue was also improved in both groups but with a significant gender difference favoring females.

Implication. Creatine supplementation improved power output and a fatigue test in both genders but females improved significantly more in a fatigue test.

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