Cassleman, M. A., Marsh, G., D., Saab, G., & Thompson, R. T. (2000). Effect of creatine supplementation on muscle metabolism during high-intensity, interval exercise. Medicine and Science in Sports and Exercise, 32(5), Supplement abstract 548.

Males (N = 11) completed 4 x 2-min bouts of constant-load wrist flexion exercise, each separated by 2-min rest. The exercise was performed before and after supplementation of ingesting 20 gm/d for five days.

Oral creatine supplementation significantly increased creatine stores in muscle but did not alter PCr metabolism or resynthesis.

Implication. One time creatine supplementation increases creatine stores but does not affect PCr metabolism.

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