Brown, G. A., Drouin, J. M., & McKenzie, D. (2005). Resistance exercise does not change the hormonal response to sublingual androstenediol intake. Medicine and Science in Sports and Exercise, 37(5), Supplement abstract 217.

"Ingesting androstenediol or androstenedione does not increase serum testosterone concentrations in men, but does elevate serum estradiol concentrations. The elevation in serum estradiol may be exaggerated by resistance exercise. Sublingual administration of androstenediol acutely increases serum testosterone concentrations. However, the effect of resistance exercise on the hormonal response, and the duration of change in serum hormones due to sublingual androstenediol are unknown". (p. S40)

Resistance trained males (N = 6) performed a single session of resistance exercise under conditions of ingesting a placebo or 21.4 mg of androstenediol. Blood samples were taken at 1, 2, 3, 4, 8, and 12 hours post-supplementation.

There were no differences in mass lifted in either condition. Resistance exercise did not alter the increase in serum estradiol or testosterone. Changes due to ingestion of androstenediol lasted less than eight hours.

Implication. Resistance training does not interact with hormonal responses due to ingestion of adrostenediol. Androsetenediol does not affect performance.

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