Kohler, R. M., Lambert, M. I., Hall, K., & Davis, S. (May, 2004). Effect of musculoskeletal injury on endogenous nandrolone metabolism. Medicine and Science in Sports and Exercise. 36(5), Supplement abstract 1159, S171.

Healthy males (N = 32; 18-50 yr) had urine samples collected within three hours of being injured. Baseline samples were collected six weeks post-injury. 19-norandrosterone (19-NA) and 19-noretiocholanolone (19-NE) were measured.

As a group, injury did not cause a significant increase in the two Nandrolone metabolites. However, there was considerable variation with one subject changing sufficiently to register a value above 2 ng/ml, which would result in a positive drug test. Endogenous Nandrolone metabolites were found in all Ss.

Implication. Nandrolone metabolites are endogenous, more so in some males than in others. Injury causes individual levels of production of 19-NA and 19-NE. One in thirty males would respond sufficiently to register a false positive in anti-drugs-in-sport testing.

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